01 Apr 09 17:33
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Ways to make Phen work better and longer

JessieGirl — This is a copy I got a few years ago from phenforum (dot) com before they started sell the herbal phen knock-off. I don't know if the supplements actually work but the lemon juice makes a HUGE difference as well as reducing caffeine intake. Here is the report cut-and-pasted...

Phentermine Tolerance

Tips To Help Decrease Your Tolerance for Phentermine

Disclaimer: This report is the result of amateur research, and is to be used solely for informational purposes, and should be seen as opinion. The information provided in this report is in no way a substitute for a consultation and advice from your doctor. As you will read, some of the tolerance- prevention methods covered in this report can cause permanent brain damage if your doctor’s instructions are not followed.

Why has Phentermine stopped helping me lose weight?

Many people are experiencing the same problem you have right now. We’re all in the same boat when it comes to being frustrated about Phentermine tolerance. For some of us, the appetite suppression diminishes within a few weeks of beginning treatment. Others enjoy the effects for a longer time, but we all seem develop tolerance eventually. So, I decided to step up to the plate and help you continue toward your weight loss goals.

Phentermine, like many other prescription drugs, work with chemicals called neurotransmitters in your brain. It actually stimulates your neuron bundles to release a particular group of neurotransmitters known as catecholamines, these include dopamine, epinephrine (formally known as adrenalin), and norepinephrine (noradrenalin). They signal a fight or flight response in your body which, in turn, puts a halt to the hunger signal. As a result, you lose your appetite because your brain doesn’t receive the hunger message. This is perhaps due to phentermine’s affects on leptin levels in the brain. It is theorized that phentermine can raise levels of leptin which signal satiety. It is also theorized that increased levels of the catecholamines are partially responsible for halting another chemical messenger know as neuropeptide Y. This chemical initiates eating, decreases energy expenditure, and increases fat storage. Here’s a simple explanation of what a neurotransmitter is:

Neurotransmitters are chemicals in your nervous system and brain. They act as messengers, relaying electrical messages between the cells (neurons) of the nervous system or brain. Some people have naturally low levels of neurotransmitters. This condition may lead to diseases such as depression, anxiety, panic attacks, and obesity, and others.

Prescription drugs work by moving neurotransmitters from one place to another, but do nothing to increase the supply of neurotransmitters in the nervous system or brain. These drugs trick your brain into thinking there are more neurotransmitters than there actually are. Because of this, your brain slows down the production of neurotransmitters.

Has Phentermine permanently depleted my supply of neurotransmitters?

We know of no studies which have shown that Phentermine can cause permanent depletion of your body’s supply of neurotransmitters in the brain and nervous system. After thorough research on the depletion of neurotransmitters by prescription drugs, we’ve concluded that it is possible to reverse the negative effects of Phentermine usage.

An independent team of researchers has developed a solution called amino acid therapy. This method of replenishing the supply of neurotransmitters is discussed below.

What steps can I take to make Phentermine effective again?

Solution 1: Amino Acid Therapy

You can do a number of things that will help to reverse the depletion of neurotransmitters by Phentermine. The first is, as mentioned in Section 2, therapy using the basic amino acids that promote production of neurotransmitters. To undergo therapy, you can take two supplements which are currently known to improve the situation.

The first supplement you can use is called D5. Developed by a company called Neuroreplete, it is designed to be used in combination with another supplement, CysReplete. It is also crucial to take a multivitamin in conjunction with these supplements to ensure adequate amounts of B vitamins which are essential to maintaining proper metabolism of nutrients in the body. If there are insufficient B vitamins ready for controlling bodily functions, they might be taken from the supplements. B vitamins are co-factors for the production of neurotransmitters from amino acids, if your body borrows them from the supplements, the production of neurotransmitters is compromised.

NOTE: Neuroreplete states that in order to use D5 safely and effectively, patients must use proper dosing of Cysreplete. Prolonged use of D5 without proper CysReplete dosage has been proven to result in irreversible dyskinesias. Dyskinesias are neurological conditions characterized by sudden episodes of abnormal involuntary muscle movements.

Do not proceed with amino acid therapy until you have talked with your physician about treatment. Your physician is the only one who can decide what dosage you should take, or if you can take these supplements at all. Proper dosage may differ between different people.

Solution 2: Less Complicated Forms Of Therapy

Studies from the Wayne Diet Clinic Nutrition Guide show that lemon water can help prevent or slow tolerance to Phentermine. The formula for lemon water contains:

2-3 ounces of lemon juice
1 quart of water
The Wayne Diet Clinic has also found that avoiding drinking sodas and other caffeinated beverages can help slow or prevent Phentermine tolerance. This is because caffeine speeds up metabolism, which has a diuretic effect and in turn causes you to excrete Phentermine from your body much more quickly through urine.

Making an overall improvement in your eating habits might play a large role in improving your production of neurotransmitters as well as other vital chemicals in the body. Since amino acids are the building blocks of neurotransmitters it is essential to ensure adequate protein in the diet. I am in no way a licensed doctor, dietician, or nutritionist; but if there was any diet I would recommend, it would be the Zone Diet. I used to have to try hard to follow the diet, balancing protein and carbohydrates, but in no time, my body was used to the diet and I was almost disgusted by unhealthy foods or unhealthy amounts of food in general. My brain power and energy shot up, as well as my overall physical condition. So, I must recommend that you try the Zone Diet in combination with taking Phentermine.

What substances should I avoid to help enable Phentermine?

You should avoid caffeinated foods and drinks as much as possible. Caffeine is a naturally- occurring substance found in the leaves, seeds or fruits of over 63 plant species worldwide and is part of a group of compounds known as methylxanthines.

The most commonly known sources of caffeine are coffee and cocoa beans, cola nuts and tea leaves. Caffeine is a pharmacologically active substance and, depending on the dose, can be a mild central nervous system stimulant. Caffeine does not accumulate in the body over the course of time and is normally excreted within several hours of consumption. It is toxic in large doses.

Caffeine speeds up the excretion of Phentermine from your body. Because of this, Phentermine has less time to suppress your appetite.

In the human brain, the centers which tell your body whether you’re hungry or full are controlled by neurotransmitters. Increased levels of the neurotransmitters called norepinephrine and dopamine suppress the feeding center. Increased levels of norepinephrine in the satiety center stimulate eating, while increased levels of serotonin in the satiety center suppress the appetite.

Some researchers theorize that tolerance to Phentermine is due to the fact that there is a limited amount of norepinephrine in the human system, and that those limited stores are depleted by repeated administration of phentermine. Others believe that the cells that respond to phentermine or norepinephrine become exhausted after repeated stimulation. Another theory is that the body is able to metabolize and excrete phentermine more and more efficiently as time passes. Eventually, the drug is metabolized so rapidly that effective blood levels are not maintained long enough for the drug to exert the desired therapeutic effect.


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01 Apr 09 23:43
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allformykids — interesting! thanks
02 Apr 09 16:13
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homzie — Do you know if the lemon juice needs to be fresh lemon juice or can it be store bought-from a container?
02 Apr 09 16:46
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JessieGirl — I was told that juice from fresh lemons is best. I used to buy them by the bag in the grocery store. One average sized lemon yields about one ounce of juice. If you press down on the lemon (hard) and roll it on the counter it will soften up and be easy to squeeze. You can also microwave it for like 10 seconds to get it soft.I am so broke right now, I think I'm going to buy a bottle of lemon juice and see if that works. It made a HUGE difference for me Image
02 Apr 09 17:14
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Streaks — I drink my vitamins! It really helps to get your vitamin supplements in liquid form. Your body absorbs it right away and you increase your seritonin levels, therefore helping your medication to work better. My favorite liquid vitamin is Vema, I mail order it through a friend. It has also helped my hair and nails to be stronger. If your depleated then you will feel sluggish and sleepy no matter what your taking.
02 Apr 09 17:24
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allformykids — What about vitamin B complex will that do? Or should I only get B12?
02 Apr 09 18:01
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myajd69 — streaks - i checked out that vemma juice...looks interesting...seems a bit pricey tho ;(
02 Apr 09 18:21
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pickles — Wow. Really interesting. Thanks for sharing
 I wish you all lived near by.  I have a lemon tree that is still full and I have given to everyone and they don't want any more.  The other day I pulled off a trash can full and threw them away, and there is still a lot on there.
Could you add any sweetner to that lemon and water?
I think I am the grandma of this group and I remember my grandma saying (and that was a long time ago) that when she wanted to lose weight she drank some kind of cider vinegar concotion; but I don't remember the details.
02 Apr 09 19:11
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yuppy4 — I used to do a "cleanse" and used organic lemons and jucied them and added water and grade B maple syrup. I am having trouble making my 504"s last. It has only been a week and they don't seem to be "working" anymore. I skipped today taking one and am going to take one tommorrow. ( I read a post that suggested that thank you for the advice ). Also, I am a huge Diet Coke drinker so I am going to try to cut that out too. I just remember the true phentermine 37.5's working so well no matter what and the 504's are really nothing compared to them but will do I guess. :)
Thanks for the information!!!
03 Apr 09 13:11
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homzie — If a person were to take B12 supplements, how much do you think a person would need to take? 
12 Apr 09 16:37
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Sugar T*ts — Bump
12 Apr 09 17:22
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deborahann15 — Thanks for the info Jessie Girl! Some really good advice! I don't think I want to try the D5, as the involuntary muscle movements may be a little irritating!Image
lol! I am going to try the lemon juice! I love lemons anyway.I wish that I lived near pickles! Also, I wanted to add that there is a lady doc named Valerie Saxion who has a website with supplements, and she has pills called smartcaps which contain the brain chemicals like dopamine and seratonin, which she says most people are low on, and both of these curb your appetite and help you lose weight, plus she says they are really good for treating depression too! I know chromium picolinate helps burn calories too. These are all natural so no side effects that I know of.Of course you want to read for yourself. The website is valeriesaxion.com.I think they are about 35.00 a bottle but they have sales. I have been meaning to order them to see if they work. I think I will now! Hope this helps somebody! Image
Deb :)
13 Apr 09 13:06
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lorielise — I've been drinking the lemon water, don't know if its helping or not, but it can't hurt, right? I can't afford lemons though, so I've been using the bottled stuff. JessieGirl, have you tried that yet? If you have, what do you think?
04 May 09 10:25
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JessieGirl — *bump*
04 May 09 18:49
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Navywife — Thanks for the post JessieGirl! I just bought some fresh lemons the other day, and I have been squeezing some into water. I also love it for the water retention! I am disappointed to hear about the caffeine, though... I love to have my coffee and diet coke! I am going to try and cut back, and see if that makes a difference.
04 May 09 18:57
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JessieGirl — Hey Navywife,
I saw your other post earlier. Are you still smiling every five minutes, LOL. Too funny! I haven't felt that in a long time! It sounds like your pills are working great so I wouldn't worry about the caffeine. Many people can't give up their coffee or soda and have good results from the phen anyway.
I used to be a huge diet coke junkie. I started slowly cutting back by drinking it on ice instead of full strength. I don't drink it at all anymore and barely drink coffee. I do drink a ton of lemonade with green tea for my caffeine fix. Now if I could just do something about the cigarettes!
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